B7 P: New ways towards the control of schistosomiasis and echinococcosis
Prof. Dr. Franco Falcone
Institut für Parasitologie
BFS - Biomedizinisches Forschungszentrum Seltersberg
Tel.: +49 (0)641-99 38030
Echinococcosis and Schistosomiasis are two co-called Neglected Tropical Diseases, which have a severe impact on the health of affected individuals in endemic countries. Our group is developing new tools that can be used for a better control of these two diseases. For schistosomiasis, we are developing new drugs that target the schistosomal Mitogen Activated Protein Kinases , in an effort to find new drugs, which are larvicidal as well as adulticidal. For Echinococcosis, we are developing a novel diagnostic platform based on detection of parasite-specific IgE using humanized IgE reporter cell lines [2-4], which can be used in a variety of formats. We are also working on extending this diagnostic platform to other parasitic infections (e.g. Fasciola, Cysticercosis, Clonorchis, Opisthorchis).
The Schistosome project aims to identify lead kinase inhibitor molecules using a bioinformatics in silico analysis pipeline and further develop these into suitable drugs, while in the Echinococcus project we are pursuing a better understanding of the protective immune responses against echinococci and aim to incorporate this knowledge into the development of vaccines and greatly improved, innovative diagnostic technologies.
DRUID Collaboration partners:
A4 Heine lab, B4 Grevelding lab, C6 NWG Häberlein lab, E5 Czermak/Salzig lab
References B7P:  *Pereira-Moreira et al. (2020) ACS Omega 5:9064-9070  Kalli M et al. (2020) Sci Rep. 10:18208  Kalli M. et al. (2020) Methods Mol Biol.;2163:155-162.  Prakash PS et al. (2021) Parasitol Res.