{"id":2502,"date":"2022-08-04T10:40:29","date_gmt":"2022-08-04T08:40:29","guid":{"rendered":"https:\/\/www.loewe-druid.de\/gruppen\/krijnse-locker\/"},"modified":"2023-11-07T11:55:01","modified_gmt":"2023-11-07T10:55:01","slug":"krijnse-locker","status":"publish","type":"portfolio","link":"https:\/\/www.loewe-druid.de\/en\/gruppen\/krijnse-locker\/","title":{"rendered":"AG Krijnse Locker"},"content":{"rendered":"<div  class='flex_column av-4pv0h7-d394881083fe5462baf0781dbc8b58c3 av_one_fourth  avia-builder-el-0  el_before_av_three_fourth  avia-builder-el-first  first flex_column_div  '     ><p>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-l639v0sh-5b19220aa33737c4ad5570dbee13b855\">\n#top .av-special-heading.av-l639v0sh-5b19220aa33737c4ad5570dbee13b855{\npadding-bottom:10px;\n}\nbody .av-special-heading.av-l639v0sh-5b19220aa33737c4ad5570dbee13b855 .av-special-heading-tag .heading-char{\nfont-size:25px;\n}\n.av-special-heading.av-l639v0sh-5b19220aa33737c4ad5570dbee13b855 .av-subheading{\nfont-size:15px;\n}\n<\/style>\n<div  class='av-special-heading av-l639v0sh-5b19220aa33737c4ad5570dbee13b855 av-special-heading-h1 blockquote modern-quote  avia-builder-el-1  el_before_av_button  avia-builder-el-first '><h1 class='av-special-heading-tag '  itemprop=\"headline\"  >AG Krijnse Locker<\/h1><div class=\"special-heading-border\"><div class=\"special-heading-inner-border\"><\/div><\/div><\/div><br \/>\n<div  class='avia-button-wrap av-l63c4nrc-24cbbc45f218bac0b9214f997166dc2a-wrap avia-button-left  avia-builder-el-2  el_after_av_heading  avia-builder-el-last '><a href='https:\/\/www.loewe-druid.de\/en\/research\/junior-research-groups-and-professorships\/'  class='avia-button av-l63c4nrc-24cbbc45f218bac0b9214f997166dc2a av-link-btn avia-icon_select-yes-left-icon avia-size-small avia-position-left avia-color-theme-color'   aria-label=\"Back to overview\"><span class='avia_button_icon avia_button_icon_left avia-iconfont avia-font-entypo-fontello' data-av_icon='\ue874' data-av_iconfont='entypo-fontello' ><\/span><span class='avia_iconbox_title' >Back to overview<\/span><\/a><\/div><\/p><\/div><div  class='flex_column av-26jz57-5f801677b6a03bad428ef58bb006d2fc av_three_fourth  avia-builder-el-3  el_after_av_one_fourth  avia-builder-el-last  flex_column_div  '     ><p>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-l63c5v2b-4d0cc7cd206ff460778db4db32c498f3\">\n#top .av-special-heading.av-l63c5v2b-4d0cc7cd206ff460778db4db32c498f3{\npadding-bottom:10px;\n}\nbody .av-special-heading.av-l63c5v2b-4d0cc7cd206ff460778db4db32c498f3 .av-special-heading-tag .heading-char{\nfont-size:25px;\n}\n.av-special-heading.av-l63c5v2b-4d0cc7cd206ff460778db4db32c498f3 .av-subheading{\nfont-size:15px;\n}\n<\/style>\n<div  class='av-special-heading av-l63c5v2b-4d0cc7cd206ff460778db4db32c498f3 av-special-heading-h3 blockquote modern-quote  avia-builder-el-4  el_before_av_gallery  avia-builder-el-first '><h3 class='av-special-heading-tag '  itemprop=\"headline\"  >The power of images<\/h3><div class='av-subheading av-subheading_below'><p>03.11.2022 \/ Text: Alexandra von Knobloch \/ Fotos: Sascha Mannel<\/p>\n<\/div><div class=\"special-heading-border\"><div class=\"special-heading-inner-border\"><\/div><\/div><\/div><br \/>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-l639wger-98dbc3df54b6fd1201337bc48ffb3169\">\n#top .avia-gallery.av-l639wger-98dbc3df54b6fd1201337bc48ffb3169 .avia-gallery-thumb a{\nwidth:33.3333%;\n}\n<\/style>\n<div  class='avia-gallery av-l639wger-98dbc3df54b6fd1201337bc48ffb3169 avia_animate_when_visible  avia-builder-el-5  el_after_av_heading  el_before_av_hr  deactivate_avia_lazyload avia-gallery-animate avia-gallery-1'  itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><meta itemprop=\"contentURL\" content=\"https:\/\/www.loewe-druid.de\/en\/gruppen\/krijnse-locker\/\"><div class='avia-gallery-thumb'><a href=\"https:\/\/www.loewe-druid.de\/wp-content\/uploads\/nachwuchsgruppen-und-professuren\/krijnse-locker\/2022-06-22_druid_z6ii_9443-1030x685.jpg\" data-srcset=\"https:\/\/www.loewe-druid.de\/wp-content\/uploads\/nachwuchsgruppen-und-professuren\/krijnse-locker\/2022-06-22_druid_z6ii_9443-1030x685.jpg 1030w, https:\/\/www.loewe-druid.de\/wp-content\/uploads\/nachwuchsgruppen-und-professuren\/krijnse-locker\/2022-06-22_druid_z6ii_9443-300x200.jpg 300w, https:\/\/www.loewe-druid.de\/wp-content\/uploads\/nachwuchsgruppen-und-professuren\/krijnse-locker\/2022-06-22_druid_z6ii_9443-768x511.jpg 768w, https:\/\/www.loewe-druid.de\/wp-content\/uploads\/nachwuchsgruppen-und-professuren\/krijnse-locker\/2022-06-22_druid_z6ii_9443-391x260.jpg 391w, https:\/\/www.loewe-druid.de\/wp-content\/uploads\/nachwuchsgruppen-und-professuren\/krijnse-locker\/2022-06-22_druid_z6ii_9443-1536x1022.jpg 1536w, https:\/\/www.loewe-druid.de\/wp-content\/uploads\/nachwuchsgruppen-und-professuren\/krijnse-locker\/2022-06-22_druid_z6ii_9443-1500x998.jpg 1500w, https:\/\/www.loewe-druid.de\/wp-content\/uploads\/nachwuchsgruppen-und-professuren\/krijnse-locker\/2022-06-22_druid_z6ii_9443-705x469.jpg 705w, https:\/\/www.loewe-druid.de\/wp-content\/uploads\/nachwuchsgruppen-und-professuren\/krijnse-locker\/2022-06-22_druid_z6ii_9443.jpg 1775w\" data-sizes=\"(max-width: 1030px) 100vw, 1030px\" data-rel='gallery-1' data-prev-img='https:\/\/www.loewe-druid.de\/wp-content\/uploads\/nachwuchsgruppen-und-professuren\/krijnse-locker\/2022-06-22_druid_z6ii_9443-495x400.jpg' class='first_thumb lightbox ' data-onclick='1' title='2022-06-22_DRUID_Z6II_9443'  itemprop=\"thumbnailUrl\"  ><img decoding=\"async\" fetchpriority=\"high\" class=\"wp-image-2119 avia-img-lazy-loading-not-2119\"   src=\"https:\/\/www.loewe-druid.de\/wp-content\/uploads\/nachwuchsgruppen-und-professuren\/krijnse-locker\/2022-06-22_druid_z6ii_9443-495x400.jpg\" width=\"495\" height=\"400\"  title='2022-06-22_DRUID_Z6II_9443' alt='' srcset=\"https:\/\/www.loewe-druid.de\/wp-content\/uploads\/nachwuchsgruppen-und-professuren\/krijnse-locker\/2022-06-22_druid_z6ii_9443-495x400.jpg 495w, https:\/\/www.loewe-druid.de\/wp-content\/uploads\/nachwuchsgruppen-und-professuren\/krijnse-locker\/2022-06-22_druid_z6ii_9443-845x684.jpg 845w\" sizes=\"(max-width: 495px) 100vw, 495px\" \/><div class='big-prev-fake'><img decoding=\"async\" loading=\"lazy\" class=\"wp-image-2119 avia-img-lazy-loading-2119\"  width=\"495\" height=\"400\" src=\"https:\/\/www.loewe-druid.de\/wp-content\/uploads\/nachwuchsgruppen-und-professuren\/krijnse-locker\/2022-06-22_druid_z6ii_9443-495x400.jpg\" title='2022-06-22_DRUID_Z6II_9443' alt='' srcset=\"https:\/\/www.loewe-druid.de\/wp-content\/uploads\/nachwuchsgruppen-und-professuren\/krijnse-locker\/2022-06-22_druid_z6ii_9443-495x400.jpg 495w, https:\/\/www.loewe-druid.de\/wp-content\/uploads\/nachwuchsgruppen-und-professuren\/krijnse-locker\/2022-06-22_druid_z6ii_9443-845x684.jpg 845w\" sizes=\"auto, (max-width: 495px) 100vw, 495px\" \/><\/div><\/a><a href=\"https:\/\/www.loewe-druid.de\/wp-content\/uploads\/nachwuchsgruppen-und-professuren\/krijnse-locker\/2022-06-22_druid_z6ii_9134-1030x685.jpg\" data-srcset=\"https:\/\/www.loewe-druid.de\/wp-content\/uploads\/nachwuchsgruppen-und-professuren\/krijnse-locker\/2022-06-22_druid_z6ii_9134-1030x685.jpg 1030w, https:\/\/www.loewe-druid.de\/wp-content\/uploads\/nachwuchsgruppen-und-professuren\/krijnse-locker\/2022-06-22_druid_z6ii_9134-300x200.jpg 300w, https:\/\/www.loewe-druid.de\/wp-content\/uploads\/nachwuchsgruppen-und-professuren\/krijnse-locker\/2022-06-22_druid_z6ii_9134-768x511.jpg 768w, https:\/\/www.loewe-druid.de\/wp-content\/uploads\/nachwuchsgruppen-und-professuren\/krijnse-locker\/2022-06-22_druid_z6ii_9134-391x260.jpg 391w, https:\/\/www.loewe-druid.de\/wp-content\/uploads\/nachwuchsgruppen-und-professuren\/krijnse-locker\/2022-06-22_druid_z6ii_9134-1536x1022.jpg 1536w, https:\/\/www.loewe-druid.de\/wp-content\/uploads\/nachwuchsgruppen-und-professuren\/krijnse-locker\/2022-06-22_druid_z6ii_9134-1500x998.jpg 1500w, https:\/\/www.loewe-druid.de\/wp-content\/uploads\/nachwuchsgruppen-und-professuren\/krijnse-locker\/2022-06-22_druid_z6ii_9134-705x469.jpg 705w, https:\/\/www.loewe-druid.de\/wp-content\/uploads\/nachwuchsgruppen-und-professuren\/krijnse-locker\/2022-06-22_druid_z6ii_9134.jpg 1775w\" data-sizes=\"(max-width: 1030px) 100vw, 1030px\" data-rel='gallery-1' data-prev-img='https:\/\/www.loewe-druid.de\/wp-content\/uploads\/nachwuchsgruppen-und-professuren\/krijnse-locker\/2022-06-22_druid_z6ii_9134-495x400.jpg' class='lightbox ' data-onclick='2' title='2022-06-22_DRUID_Z6II_9134'  itemprop=\"thumbnailUrl\"  ><img decoding=\"async\" fetchpriority=\"high\" class=\"wp-image-2115 avia-img-lazy-loading-not-2115\"   src=\"https:\/\/www.loewe-druid.de\/wp-content\/uploads\/nachwuchsgruppen-und-professuren\/krijnse-locker\/2022-06-22_druid_z6ii_9134-495x400.jpg\" width=\"495\" height=\"400\"  title='2022-06-22_DRUID_Z6II_9134' alt='' srcset=\"https:\/\/www.loewe-druid.de\/wp-content\/uploads\/nachwuchsgruppen-und-professuren\/krijnse-locker\/2022-06-22_druid_z6ii_9134-495x400.jpg 495w, https:\/\/www.loewe-druid.de\/wp-content\/uploads\/nachwuchsgruppen-und-professuren\/krijnse-locker\/2022-06-22_druid_z6ii_9134-845x684.jpg 845w\" sizes=\"(max-width: 495px) 100vw, 495px\" \/><div class='big-prev-fake'><img decoding=\"async\" loading=\"lazy\" class=\"wp-image-2115 avia-img-lazy-loading-2115\"  width=\"495\" height=\"400\" src=\"https:\/\/www.loewe-druid.de\/wp-content\/uploads\/nachwuchsgruppen-und-professuren\/krijnse-locker\/2022-06-22_druid_z6ii_9134-495x400.jpg\" title='2022-06-22_DRUID_Z6II_9134' alt='' srcset=\"https:\/\/www.loewe-druid.de\/wp-content\/uploads\/nachwuchsgruppen-und-professuren\/krijnse-locker\/2022-06-22_druid_z6ii_9134-495x400.jpg 495w, https:\/\/www.loewe-druid.de\/wp-content\/uploads\/nachwuchsgruppen-und-professuren\/krijnse-locker\/2022-06-22_druid_z6ii_9134-845x684.jpg 845w\" sizes=\"auto, (max-width: 495px) 100vw, 495px\" \/><\/div><\/a><a href=\"https:\/\/www.loewe-druid.de\/wp-content\/uploads\/nachwuchsgruppen-und-professuren\/krijnse-locker\/2022-06-22_druid_z6ii_10044-1030x685.jpg\" data-srcset=\"https:\/\/www.loewe-druid.de\/wp-content\/uploads\/nachwuchsgruppen-und-professuren\/krijnse-locker\/2022-06-22_druid_z6ii_10044-1030x685.jpg 1030w, https:\/\/www.loewe-druid.de\/wp-content\/uploads\/nachwuchsgruppen-und-professuren\/krijnse-locker\/2022-06-22_druid_z6ii_10044-300x200.jpg 300w, https:\/\/www.loewe-druid.de\/wp-content\/uploads\/nachwuchsgruppen-und-professuren\/krijnse-locker\/2022-06-22_druid_z6ii_10044-768x511.jpg 768w, https:\/\/www.loewe-druid.de\/wp-content\/uploads\/nachwuchsgruppen-und-professuren\/krijnse-locker\/2022-06-22_druid_z6ii_10044-391x260.jpg 391w, https:\/\/www.loewe-druid.de\/wp-content\/uploads\/nachwuchsgruppen-und-professuren\/krijnse-locker\/2022-06-22_druid_z6ii_10044-1536x1022.jpg 1536w, https:\/\/www.loewe-druid.de\/wp-content\/uploads\/nachwuchsgruppen-und-professuren\/krijnse-locker\/2022-06-22_druid_z6ii_10044-1500x998.jpg 1500w, https:\/\/www.loewe-druid.de\/wp-content\/uploads\/nachwuchsgruppen-und-professuren\/krijnse-locker\/2022-06-22_druid_z6ii_10044-705x469.jpg 705w, https:\/\/www.loewe-druid.de\/wp-content\/uploads\/nachwuchsgruppen-und-professuren\/krijnse-locker\/2022-06-22_druid_z6ii_10044.jpg 1775w\" data-sizes=\"(max-width: 1030px) 100vw, 1030px\" data-rel='gallery-1' data-prev-img='https:\/\/www.loewe-druid.de\/wp-content\/uploads\/nachwuchsgruppen-und-professuren\/krijnse-locker\/2022-06-22_druid_z6ii_10044-495x400.jpg' class='lightbox ' data-onclick='3' title='2022-06-22_DRUID_Z6II_10044'  itemprop=\"thumbnailUrl\"  ><img decoding=\"async\" fetchpriority=\"high\" class=\"wp-image-2057 avia-img-lazy-loading-not-2057\"   src=\"https:\/\/www.loewe-druid.de\/wp-content\/uploads\/nachwuchsgruppen-und-professuren\/krijnse-locker\/2022-06-22_druid_z6ii_10044-495x400.jpg\" width=\"495\" height=\"400\"  title='2022-06-22_DRUID_Z6II_10044' alt='' srcset=\"https:\/\/www.loewe-druid.de\/wp-content\/uploads\/nachwuchsgruppen-und-professuren\/krijnse-locker\/2022-06-22_druid_z6ii_10044-495x400.jpg 495w, https:\/\/www.loewe-druid.de\/wp-content\/uploads\/nachwuchsgruppen-und-professuren\/krijnse-locker\/2022-06-22_druid_z6ii_10044-845x684.jpg 845w\" sizes=\"(max-width: 495px) 100vw, 495px\" \/><div class='big-prev-fake'><img decoding=\"async\" loading=\"lazy\" class=\"wp-image-2057 avia-img-lazy-loading-2057\"  width=\"495\" height=\"400\" src=\"https:\/\/www.loewe-druid.de\/wp-content\/uploads\/nachwuchsgruppen-und-professuren\/krijnse-locker\/2022-06-22_druid_z6ii_10044-495x400.jpg\" title='2022-06-22_DRUID_Z6II_10044' alt='' srcset=\"https:\/\/www.loewe-druid.de\/wp-content\/uploads\/nachwuchsgruppen-und-professuren\/krijnse-locker\/2022-06-22_druid_z6ii_10044-495x400.jpg 495w, https:\/\/www.loewe-druid.de\/wp-content\/uploads\/nachwuchsgruppen-und-professuren\/krijnse-locker\/2022-06-22_druid_z6ii_10044-845x684.jpg 845w\" sizes=\"auto, (max-width: 495px) 100vw, 495px\" \/><\/div><\/a><a href=\"https:\/\/www.loewe-druid.de\/wp-content\/uploads\/nachwuchsgruppen-und-professuren\/krijnse-locker\/2022-06-22_druid_z6ii_10279-1030x685.jpg\" data-srcset=\"https:\/\/www.loewe-druid.de\/wp-content\/uploads\/nachwuchsgruppen-und-professuren\/krijnse-locker\/2022-06-22_druid_z6ii_10279-1030x685.jpg 1030w, https:\/\/www.loewe-druid.de\/wp-content\/uploads\/nachwuchsgruppen-und-professuren\/krijnse-locker\/2022-06-22_druid_z6ii_10279-300x200.jpg 300w, https:\/\/www.loewe-druid.de\/wp-content\/uploads\/nachwuchsgruppen-und-professuren\/krijnse-locker\/2022-06-22_druid_z6ii_10279-768x511.jpg 768w, https:\/\/www.loewe-druid.de\/wp-content\/uploads\/nachwuchsgruppen-und-professuren\/krijnse-locker\/2022-06-22_druid_z6ii_10279-391x260.jpg 391w, https:\/\/www.loewe-druid.de\/wp-content\/uploads\/nachwuchsgruppen-und-professuren\/krijnse-locker\/2022-06-22_druid_z6ii_10279-1536x1022.jpg 1536w, https:\/\/www.loewe-druid.de\/wp-content\/uploads\/nachwuchsgruppen-und-professuren\/krijnse-locker\/2022-06-22_druid_z6ii_10279-1500x998.jpg 1500w, https:\/\/www.loewe-druid.de\/wp-content\/uploads\/nachwuchsgruppen-und-professuren\/krijnse-locker\/2022-06-22_druid_z6ii_10279-705x469.jpg 705w, https:\/\/www.loewe-druid.de\/wp-content\/uploads\/nachwuchsgruppen-und-professuren\/krijnse-locker\/2022-06-22_druid_z6ii_10279.jpg 1775w\" data-sizes=\"(max-width: 1030px) 100vw, 1030px\" data-rel='gallery-1' data-prev-img='https:\/\/www.loewe-druid.de\/wp-content\/uploads\/nachwuchsgruppen-und-professuren\/krijnse-locker\/2022-06-22_druid_z6ii_10279-495x400.jpg' class='first_thumb lightbox ' data-onclick='4' title='2022-06-22_DRUID_Z6II_10279'  itemprop=\"thumbnailUrl\"  ><img decoding=\"async\" fetchpriority=\"high\" class=\"wp-image-2416 avia-img-lazy-loading-not-2416\"   src=\"https:\/\/www.loewe-druid.de\/wp-content\/uploads\/nachwuchsgruppen-und-professuren\/krijnse-locker\/2022-06-22_druid_z6ii_10279-495x400.jpg\" width=\"495\" height=\"400\"  title='2022-06-22_DRUID_Z6II_10279' alt='' srcset=\"https:\/\/www.loewe-druid.de\/wp-content\/uploads\/nachwuchsgruppen-und-professuren\/krijnse-locker\/2022-06-22_druid_z6ii_10279-495x400.jpg 495w, https:\/\/www.loewe-druid.de\/wp-content\/uploads\/nachwuchsgruppen-und-professuren\/krijnse-locker\/2022-06-22_druid_z6ii_10279-845x684.jpg 845w\" sizes=\"(max-width: 495px) 100vw, 495px\" \/><div class='big-prev-fake'><img decoding=\"async\" loading=\"lazy\" class=\"wp-image-2416 avia-img-lazy-loading-2416\"  width=\"495\" height=\"400\" src=\"https:\/\/www.loewe-druid.de\/wp-content\/uploads\/nachwuchsgruppen-und-professuren\/krijnse-locker\/2022-06-22_druid_z6ii_10279-495x400.jpg\" title='2022-06-22_DRUID_Z6II_10279' alt='' srcset=\"https:\/\/www.loewe-druid.de\/wp-content\/uploads\/nachwuchsgruppen-und-professuren\/krijnse-locker\/2022-06-22_druid_z6ii_10279-495x400.jpg 495w, https:\/\/www.loewe-druid.de\/wp-content\/uploads\/nachwuchsgruppen-und-professuren\/krijnse-locker\/2022-06-22_druid_z6ii_10279-845x684.jpg 845w\" sizes=\"auto, (max-width: 495px) 100vw, 495px\" \/><\/div><\/a><a href=\"https:\/\/www.loewe-druid.de\/wp-content\/uploads\/nachwuchsgruppen-und-professuren\/krijnse-locker\/2022-06-22_druid_z6ii_9228-1030x685.jpg\" data-srcset=\"https:\/\/www.loewe-druid.de\/wp-content\/uploads\/nachwuchsgruppen-und-professuren\/krijnse-locker\/2022-06-22_druid_z6ii_9228-1030x685.jpg 1030w, https:\/\/www.loewe-druid.de\/wp-content\/uploads\/nachwuchsgruppen-und-professuren\/krijnse-locker\/2022-06-22_druid_z6ii_9228-300x200.jpg 300w, https:\/\/www.loewe-druid.de\/wp-content\/uploads\/nachwuchsgruppen-und-professuren\/krijnse-locker\/2022-06-22_druid_z6ii_9228-768x511.jpg 768w, 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class=\"wp-image-2049 avia-img-lazy-loading-2049\"  width=\"495\" height=\"400\" src=\"https:\/\/www.loewe-druid.de\/wp-content\/uploads\/nachwuchsgruppen-und-professuren\/krijnse-locker\/2022-06-22_druid_z6ii_8645-495x400.jpg\" title='2022-06-22_DRUID_Z6II_8645' alt='' srcset=\"https:\/\/www.loewe-druid.de\/wp-content\/uploads\/nachwuchsgruppen-und-professuren\/krijnse-locker\/2022-06-22_druid_z6ii_8645-495x400.jpg 495w, https:\/\/www.loewe-druid.de\/wp-content\/uploads\/nachwuchsgruppen-und-professuren\/krijnse-locker\/2022-06-22_druid_z6ii_8645-845x684.jpg 845w\" sizes=\"auto, (max-width: 495px) 100vw, 495px\" \/><\/div><\/a><\/div><\/div><br \/>\n<div  class='hr av-2jk2zv-b8421b839a4c6ca17f1b4df0671cb0b6 hr-default  avia-builder-el-6  el_after_av_gallery  el_before_av_textblock '><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div><br \/>\n<section  class='av_textblock_section av-l639vu7v-01ae1eebaa334c8fe4c53946ac422ca9 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><p><strong>The power of images<\/strong><\/p>\n<p><em>Using imaging techniques, in particular electron microscopy, Prof. Dr. Jacomina Krijnse Locker studies how viruses reprogram their host. In the process, she looks for targets to eliminate the pathogen. <\/em><\/p>\n<p>How do viruses multiply? This question many people may have asked during the Corona pandemic. Those looking for in-depth answers quickly realize that science cannot explain it down to the last detail yet.<\/p>\n<p>Viruses hijack the host cell, that much is certain. Equipped with little genetic material they manage to manipulate the cell such that it produces and releases masses of new viruses. Host cell membranes play a role in this process, as does the cytoskeleton, structures that provide cells with a frame. But what happens exactly in the host cells during infection? How do the multiplication strategies of viruses differ? Can specific steps of the viral replication cycle be stopped, thus offering a therapeutic approach?<\/p>\n<p><strong>Viruses: &#8220;Fascinating and terrifying&#8221;<\/strong><\/p>\n<p>Prof. Dr. Jacomina Krijnse Locker has been working on such research questions since the 1990s. She addresses these by directly observing viruses in their host cells: under the electron microscope (EM), with advanced light microscopes, and with the combination of both, correlative light- and electron microscopy (CLEM). The way viruses manipulate their host is both &#8220;Fascinating and terrifying&#8221;, she wrote in a recent <a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1111\/mmi.14950\"><strong><u>editorial<\/u><\/strong><\/a> for the journal Molecular Microbiology. The SARS-CoV-2 pandemic proved that again, underscoring the need for fundamental research in the virus field.<\/p>\n<p>The 64-year-old electron microscopy expert originates from the Netherlands. Her first professional position, in the faculty of veterinary medicine in Utrecht, led her to work on corona viruses in the research group of Prof. Peter Rottier. &#8220;In those days, hardly anyone outside of veterinary medicine was interested in corona viruses,&#8221; reports the head of the &#8220;Electron Microscopy of Pathogens Research Group&#8221; at the Paul Ehrlich Institute (PEI) in Langen near Frankfurt am Main. &#8220;They caused severe disease in animals, such as pigs, cats, mice, chicken and were considered harmless common-cold viruses in humans.&#8221; Her early expertise in Corona viruses is as useful to Krijnse Locker&#8217;s work today as her knowledge of vaccinia virus \u2013 the vaccine strain that lead to the eradication of smallpox, flaviviruses, several of which cause serious diseases in tropical countries, or the HI virus.<\/p>\n<p><strong>The challenge begins with sample preparation<\/strong><\/p>\n<p>In electron microscopy (EM), experience gives you a head start. The aim is to generate scientifically meaningful images of particles much smaller than cells &#8211; including viruses. In EM the scientific challenge begins long before the actual imaging of the cell&#8217;s interior. It lies in the preparation of the sample.<\/p>\n<p>The structures that researchers want to see have to be properly identified in the first place &#8211; in a microworld where less than a nanometer (a millionth of a millimeter) makes huge differences. They should not be destroyed or altered by the preparation for EM. After all, scientists want to observe the processes in the host cell as close to reality as possible without preparation artifacts.<\/p>\n<p><strong>Viral pathogens of tropical diseases in comparison<\/strong><\/p>\n<p>Finding the right conditions for the preparation of samples is sometimes very time-consuming. Weeks and months can pass before something appears on the screen of an EM that can be scientifically evaluated. In the projects funded by the <strong><u>LOEWE center DRUID<\/u><\/strong>, Jacomina Krijnse Locker and her team are working on a special challenge: In cooperation with other DRUID groups, they study various viruses that cause tropical diseases that so far cannot be treated. Among these are flaviviruses that Krijnse Locker has worked on previously, such as Zika virus, West Nile virus, Dengue virus, as well as the Bunyavirus Rift Valley Fever virus.<\/p>\n<p>Her team includes two technical assistants, two postdoctoral fellows and two graduate students. &#8220;We are trying to establish routine procedures as a basis for studying different viruses,&#8221; Krijnse Locker explains. &#8220;Although we are already quite far, such working protocols will need to be adapted to different viruses and their respective questions.&#8221;<\/p>\n<p><strong>Important findings on SARS-CoV-2 during the pandemic<\/strong><\/p>\n<p>In 2020, Jacomina Krijnse Locker accepted the DRUID professorship &#8220;Neglected Infectious Diseases with a Focus on Imaging&#8221; at the University of Giessen together with the PEI according to the so-called J\u00fclich Model. She works with her group at PEI and teaches in parallel at the University of Giessen in the Department 08 of Biology and Chemistry. Only 6 weeks after her start, her lab was hit by the first Coronavirus lockdown. This is where her Corona expertise paid off; rather than staying at home Krijnse Locker successfully isolated and purified SARS-CoV-2 and together with collaborating teams found out important details about the spike protein.<\/p>\n<p>Working in an EM lab requires a steady hand and a lot of endurance. After preparing the samples, the next challenge is to correctly interpret what the images on the monitor mean; \u201cIs that really a membrane structure around a virus, or does it belong to the host cell?\u201d Is it possible that you are looking at something that has nothing to do with the research question? If something important is seen in the microscope, the observations need to be checked and validated- using other microscopic methods, by quantifying the observations and analysing the images. From the time a single image is captured it is still a long way to better understand disease-causing viruses.<\/p>\n<p><strong>Dutch special path to research career<\/strong><\/p>\n<p>Jacomina Krijnse Locker says she immediately became excited about imaging the first time she sat in front of a microscope. Before she already realized that she wanted to work with pathogens. Right after graduating from high school, it wasn&#8217;t so clear.<\/p>\n<p>&#8220;I didn&#8217;t really know what I wanted and first completed a study to become a technical assistant,&#8221; she reports. However, already during her first position in a research laboratory she realized that she wanted to do research. After several years of technical assistant, she went on to do her PhD on corona viruses at the University of Utrecht, without university degree which is possible in the Netherlands. After her PhD she worked at the &#8220;European Molecular Biology Laboratory&#8221; (EMBL) in Heidelberg and habilitated at the University of Heidelberg, where she subsequently headed the Electron Microscopy Core Facility. From 2015 to 2019, she was responsible for the Electron Microscopy Unit at the Institut Pasteur in Paris.<\/p>\n<p>Germany, she says, &#8220;offers a very good environment for electron microscopy.&#8221; There is plenty of state-of-the-art equipment and the appropriate expertise to keep each other up to date, she says. The DRUID project enables an open exchange, something that was missing in Pasteur, she says: &#8220;We find each other and cooperate in an uncomplicated way. It helps achieve DRUID&#8217;s overall goal: identifying potential targets and drugs to treat neglected tropical infectious diseases.<\/p>\n<p><strong>Many groundbreaking findings in virology are brand new <\/strong><\/p>\n<p>Observing viruses directly in the host cell has two sides, says Krijnse Locker: &#8220;It teaches us about the virus and about the cell.&#8221; This increases the prospects of finding medically relevant targets that destroy the viruses without harming the host. Currently, Jacomina Krijnse Locker focuses on how viruses leave their host, to enter and infect other cells.<\/p>\n<p>As always in science, new findings immediately raise new questions. &#8220;How do viruses manipulate their host so that the steps the virus needs to multiply are as efficient as possible? So that everything takes place in the host cell at the right time and at the right place? And at the same time, how do viruses manage to ensure that the host cell does not die immediately?&#8221; summarizes Krijnse Locker. There is still much to discover in the electron microscope.<\/p>\n<\/div><\/section><br \/>\n<div  class='hr av-2rb5aj-710a2676bdd75b52a17f221a70e518da hr-default  avia-builder-el-8  el_after_av_textblock  el_before_av_heading '><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div><br \/>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-l63f10o6-5764c912b84853fd5599ec7c54503ffd\">\n#top .av-special-heading.av-l63f10o6-5764c912b84853fd5599ec7c54503ffd{\npadding-bottom:10px;\n}\nbody .av-special-heading.av-l63f10o6-5764c912b84853fd5599ec7c54503ffd .av-special-heading-tag .heading-char{\nfont-size:25px;\n}\n.av-special-heading.av-l63f10o6-5764c912b84853fd5599ec7c54503ffd .av-subheading{\nfont-size:15px;\n}\n<\/style>\n<div  class='av-special-heading av-l63f10o6-5764c912b84853fd5599ec7c54503ffd av-special-heading-h3 blockquote modern-quote  avia-builder-el-9  el_after_av_hr  el_before_av_pl_liste '><h3 class='av-special-heading-tag '  itemprop=\"headline\"  >Contact<\/h3><div class=\"special-heading-border\"><div class=\"special-heading-inner-border\"><\/div><\/div><\/div><br \/>\n<h4 class=\"orga-headline\"><\/h4><ul><li><a href=\"#projektleiter-47\" class=\"open_popup no-scroll\" onclick=\"attach_magnific_popup(event)\">Prof. Dr. Jacomina Krijnse Locker<\/a><\/li><\/ul><div id=\"projektleiter-47\" class=\"projektleiter-modal mfp-hide\">   <button title=\"Close (Esc)\" type=\"button\" class=\"mfp-close mfp-close-custom\">\u00d7<\/button>   <div class=\"modal-inner\">       <img loading=\"lazy\" decoding=\"async\" style=\"float:right;\" src=\"https:\/\/www.loewe-druid.de\/wp-content\/uploads\/pls2022\/jacomina-krijnse-locker.jpg\" width=\"1000\" height=\"667\" \/>       <h4>Prof. Dr. Jacomina Krijnse Locker<\/h4>       <p><p>Elektronenmikroskopie von Pathogenen<br \/>\nPaul-Ehrlich-Institut<br \/>\nPaul-Ehrlich-Stra\u00dfe 51-59<br \/>\n63225 Langen<br \/>\nTel.: +49 (0)6103-77 2011<br \/>\nE-Mail: <a class=\"mail\" href=\"mailto:Jacomina.KrijnseLocker@pei.de\">Jacomina.KrijnseLocker(at)pei(dot)de<\/a><\/p>\n<\/p>   <\/div><\/div><\/p><\/div><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":2119,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"tags":[],"portfolio_entries":[104],"class_list":["post-2502","portfolio","type-portfolio","status-publish","has-post-thumbnail","hentry","portfolio_entries-professuren-en"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.4 - 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