{"id":2230,"date":"2022-08-09T10:36:29","date_gmt":"2022-08-09T08:36:29","guid":{"rendered":"https:\/\/www.loewe-druid.de\/gruppen\/haeberlein\/"},"modified":"2023-11-07T11:55:01","modified_gmt":"2023-11-07T10:55:01","slug":"haeberlein","status":"publish","type":"portfolio","link":"https:\/\/www.loewe-druid.de\/en\/gruppen\/haeberlein\/","title":{"rendered":"AG H\u00e4berlein"},"content":{"rendered":"<div  class='flex_column av-4pv0h7-d394881083fe5462baf0781dbc8b58c3 av_one_fourth  avia-builder-el-0  el_before_av_three_fourth  avia-builder-el-first  first flex_column_div  '     ><p>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-l639v0sh-27edd78927c902afa15ba8be5d68c6af\">\n#top .av-special-heading.av-l639v0sh-27edd78927c902afa15ba8be5d68c6af{\npadding-bottom:10px;\n}\nbody .av-special-heading.av-l639v0sh-27edd78927c902afa15ba8be5d68c6af .av-special-heading-tag .heading-char{\nfont-size:25px;\n}\n.av-special-heading.av-l639v0sh-27edd78927c902afa15ba8be5d68c6af .av-subheading{\nfont-size:15px;\n}\n<\/style>\n<div  class='av-special-heading av-l639v0sh-27edd78927c902afa15ba8be5d68c6af av-special-heading-h1 blockquote modern-quote  avia-builder-el-1  el_before_av_button  avia-builder-el-first '><h1 class='av-special-heading-tag '  itemprop=\"headline\"  >AG H\u00e4berlein<\/h1><div class=\"special-heading-border\"><div class=\"special-heading-inner-border\"><\/div><\/div><\/div><br \/>\n<div  class='avia-button-wrap av-l63c4nrc-24cbbc45f218bac0b9214f997166dc2a-wrap avia-button-left  avia-builder-el-2  el_after_av_heading  avia-builder-el-last '><a href='https:\/\/www.loewe-druid.de\/en\/research\/junior-research-groups-and-professorships\/'  class='avia-button av-l63c4nrc-24cbbc45f218bac0b9214f997166dc2a av-link-btn avia-icon_select-yes-left-icon avia-size-small avia-position-left avia-color-theme-color'   aria-label=\"Back to overview\"><span class='avia_button_icon avia_button_icon_left avia-iconfont avia-font-entypo-fontello' data-av_icon='\ue874' data-av_iconfont='entypo-fontello' ><\/span><span class='avia_iconbox_title' >Back to overview<\/span><\/a><\/div><\/p><\/div><div  class='flex_column av-26jz57-5f801677b6a03bad428ef58bb006d2fc av_three_fourth  avia-builder-el-3  el_after_av_one_fourth  avia-builder-el-last  flex_column_div  '     ><p>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-l63c5v2b-88aaa34ca23ea8af5a8c6df002cce5b3\">\n#top .av-special-heading.av-l63c5v2b-88aaa34ca23ea8af5a8c6df002cce5b3{\npadding-bottom:10px;\n}\nbody .av-special-heading.av-l63c5v2b-88aaa34ca23ea8af5a8c6df002cce5b3 .av-special-heading-tag .heading-char{\nfont-size:25px;\n}\n.av-special-heading.av-l63c5v2b-88aaa34ca23ea8af5a8c6df002cce5b3 .av-subheading{\nfont-size:15px;\n}\n<\/style>\n<div  class='av-special-heading av-l63c5v2b-88aaa34ca23ea8af5a8c6df002cce5b3 av-special-heading-h3 blockquote modern-quote  avia-builder-el-4  el_before_av_gallery  avia-builder-el-first '><h3 class='av-special-heading-tag '  itemprop=\"headline\"  >Passion for unknown ways<\/h3><div class='av-subheading av-subheading_below'><p>03.11.2022 \/ Text: Alexandra von Knobloch \/ Fotos: Sascha Mannel<\/p>\n<\/div><div class=\"special-heading-border\"><div class=\"special-heading-inner-border\"><\/div><\/div><\/div><br \/>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-l639wger-513cc248d38fc18a4ffd7890fb82f71a\">\n#top .avia-gallery.av-l639wger-513cc248d38fc18a4ffd7890fb82f71a .avia-gallery-thumb a{\nwidth:33.3333%;\n}\n<\/style>\n<div  class='avia-gallery av-l639wger-513cc248d38fc18a4ffd7890fb82f71a avia_animate_when_visible  avia-builder-el-5  el_after_av_heading  el_before_av_hr  deactivate_avia_lazyload avia-gallery-animate avia-gallery-1'  itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><meta itemprop=\"contentURL\" 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class='big-prev-fake'><img decoding=\"async\" loading=\"lazy\" class=\"wp-image-2029 avia-img-lazy-loading-2029\"  width=\"495\" height=\"400\" src=\"https:\/\/www.loewe-druid.de\/wp-content\/uploads\/nachwuchsgruppen-und-professuren\/haeberlein\/2022-06-15_druid_z6ii_4316-495x400.jpg\" title='2022-06-15_DRUID_Z6II_4316' alt='' srcset=\"https:\/\/www.loewe-druid.de\/wp-content\/uploads\/nachwuchsgruppen-und-professuren\/haeberlein\/2022-06-15_druid_z6ii_4316-495x400.jpg 495w, https:\/\/www.loewe-druid.de\/wp-content\/uploads\/nachwuchsgruppen-und-professuren\/haeberlein\/2022-06-15_druid_z6ii_4316-845x684.jpg 845w\" sizes=\"auto, (max-width: 495px) 100vw, 495px\" \/><\/div><\/a><\/div><\/div><br \/>\n<div  class='hr av-2jk2zv-b8421b839a4c6ca17f1b4df0671cb0b6 hr-default  avia-builder-el-6  el_after_av_gallery  el_before_av_textblock '><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div><br \/>\n<section  class='av_textblock_section av-l639vu7v-01ae1eebaa334c8fe4c53946ac422ca9 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><p><strong>Passion for unknown paths<\/strong><\/p>\n<p><em>Dr. Simone H\u00e4berlein, who has just completed her professorial qualification, heads a junior research group that studies tropical worm parasites. Her work makes use of the latest methods\u2014and a classic research spirit.<\/em><\/p>\n<p>Being creative: This is how Simone H\u00e4berlein describes what fascinates her most about her job. If you think she is a painter, designer or book author, you&#8217;re wrong. The 40-year-old woman from Bavaria is a biologist (PD Dr. <em>rer. nat.<\/em>), has a professorial qualification in zoology and molecular biology, and conducts basic research. Parasitic worms are her field of expertise. Her career as a scientist revolves around finding out more about how these parasites manipulate their host organism and how\u2014conversely\u2014the host affects the creature that has infested it.<\/p>\n<p>H\u00e4berlein and her colleagues are investigating this interaction at the molecular level, i.e. in an area invisible to the naked eye and where only some microscopes can still penetrate. Anyone working in this field needs a high level of abstraction and analytical thinking.<\/p>\n<p>But this is not the terminology that comes to her mind when she talks about what she does. She emphasizes creativity. \u201cAs a scientist, I have the freedom to look for unresolved questions and think of ways to answer them,\u201d she says.<\/p>\n<p><strong>Dream job: scientist<\/strong><\/p>\n<p>She and her team are investigating a specific class of enzymes, the protein kinases, and want to clarify which of these kinases are produced &#8211; and where in the parasite&#8217;s body &#8211; under certain environmental conditions. In biology, such methods are called omics analyses. They allow very complex processes in cells to be visualized, and it has only been in the last few years that even two-dimensional analyses, i.e. in a spatial context, have become technically possible. \u201cAs far as I know, we are the first working group in the world to apply this on liver flukes,\u201d H\u00e4berlein reports. She is expecting \u201cgroundbreaking results for the next ten years.\u201d<\/p>\n<p>The long-term goal behind H\u00e4berlein&#8217;s LOEWE project is ambitious: DRUID, funded by the German state of Hesse, seeks to help develop new therapies for neglected tropical diseases that primarily afflict the poorer populations of emerging and developing countries. Fasciolosis, an infection with liver flukes, is on the list of diseases for which the World Health Organization (WHO) sees a particularly urgent need for action.<\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<p><strong>Inspiration from cancer research<\/strong><\/p>\n<p><a href=\"https:\/\/www.loewe-druid.de\/en\/research\/project-area-c\/#toggle-id-1\">H\u00e4berlein\u2019s DRUID project<\/a> is called \u2018The <em>Fasciola<\/em> kinome as a source for new drug targets\u2019. Her initial hypothesis: If a protein kinase could be found that is essential for the liver fluke to survive, this would be a possible starting point for developing a drug that kills liver flukes. How did she come up with it? Cancer therapy provided the inspiration. Drugs against protein kinases, or kinase inhibitors, have been used for quite a while to destroy cancer cells. The creative transfer of this concept to the worm parasite <em>Schistosoma<\/em> has already proved successful by colleagues in Giessen. With transfer of this concept to fasciolosis, the idea of a promising new methodology, and a successful project proposal for a DRUID junior research group, the work is running at full steam now.<\/p>\n<p>DRUID supports H\u00e4berlein&#8217;s junior research group with a PhD student position and a part-time position for technical assistants. In total, this molecular biologist heads five doctoral students, a medical technician, and a chemistry lab technician in her interdisciplinary, international team. In addition to biologists, the team includes a veterinarian and a biophysicist. \u201cThis support is particularly valuable for me,\u201d says H\u00e4berlein. The more experts are involved in a scientific study, the faster it progresses.<\/p>\n<p><strong>Only a few experts worldwide<\/strong><\/p>\n<p>H\u00e4berlein herself is one of the world&#8217;s experts in liver fluke molecular biology and is also intensively involved with another trematode (parasitic flatworm), the blood fluke <em>Schistosoma mansoni<\/em>. This parasite causes another severe, neglected tropical disease, schistosomiasis, also known as bilharzia. H\u00e4berlein had already been involved in a project during the first funding phase of DRUID, and important findings from this work were incorporated into her professorial dissertation.<\/p>\n<p>Right now, she sees herself in the right spot at the right time, riding the \u201cwave of science\u201d . H\u00e4berlein focuses on basic research, the essential findings that enable translational research later on. \u201cI&#8217;m interested in understanding in detail the interplay between the parasites and the hosts at the level of gene products: transcripts and proteins.\u201d With this knowledge, a new drug target can be identified.<\/p>\n<p>Along with &#8216;creative&#8217;, &#8216;exciting&#8217; is a word H\u00e4berlein often uses. She refers to biology itself as \u2018science of the laws of animate nature\u2019. She is driven by the desire to fathom these rules and interrelationships. As early as the eighth grade at school, she wanted to study biology, which she then did at the University of Erlangen.<\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<p><strong>Parasitology since her graduate thesis<\/strong><\/p>\n<p>Her interests were very broad at first. \u201cI took twice as many internships as I needed,\u201d she says, \u201czoology, geobotany, virology, everything across the board.\u201d Then, during her thesis, she had her first exposure to parasitology. She worked with cercariae\u2014worm larvae that bore through the skin into the body and lurk in waterbodies. \u201cEver since, parasitology has fascinated me,\u201d H\u00e4berlein says. After earning her doctorate in Erlangen and spending three years as a postdoc at the Leiden University Medical Center in the Netherlands, she returned to Germany. Christoph Grevelding brought her to the Institute of Parasitology at Justus Liebig University in Giessen. Then came DRUID.<\/p>\n<p>The work in this research program also involves numerous international collaborations. &#8220;We have already been able to involve guest scientists from C\u00f4te d&#8217;Ivoire and Egypt in our work and can thus pass on our knowledge to affected countries,&#8221; reports H\u00e4berlein. The work on neglected tropical diseases is urgent &#8211; for humanitarian reasons, but also because the pathogens are spreading.<\/p>\n<p><strong>New conditions due to global warming<\/strong><\/p>\n<p>Take schistosomiasis, for example. Currently, there is a drug that works well against it, praziquantel. Experts assume that the pathogens will increasingly develop resistance to it in the foreseeable future. At the same time, the pathogens are spreading due to global warming. Schistosomiasis, for example, has now reached Portugal and Corsica. \u201cWe should prepare ourselves,\u201d H\u00e4berlein says. \u201cThat&#8217;s why we&#8217;re trying to find new active substances against parasites,\u201d ideally, ones that can be used against multiple worm species at once. Is this possible? Simone H\u00e4berlein&#8217;s omics experiments could help answer this unresolved research question.<\/p>\n<\/div><\/section><br \/>\n<div  class='hr av-2rb5aj-710a2676bdd75b52a17f221a70e518da hr-default  avia-builder-el-8  el_after_av_textblock  el_before_av_heading '><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div><br \/>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-l63f10o6-5764c912b84853fd5599ec7c54503ffd\">\n#top .av-special-heading.av-l63f10o6-5764c912b84853fd5599ec7c54503ffd{\npadding-bottom:10px;\n}\nbody .av-special-heading.av-l63f10o6-5764c912b84853fd5599ec7c54503ffd .av-special-heading-tag .heading-char{\nfont-size:25px;\n}\n.av-special-heading.av-l63f10o6-5764c912b84853fd5599ec7c54503ffd .av-subheading{\nfont-size:15px;\n}\n<\/style>\n<div  class='av-special-heading av-l63f10o6-5764c912b84853fd5599ec7c54503ffd av-special-heading-h3 blockquote modern-quote  avia-builder-el-9  el_after_av_hr  el_before_av_pl_liste '><h3 class='av-special-heading-tag '  itemprop=\"headline\"  >Contact<\/h3><div class=\"special-heading-border\"><div class=\"special-heading-inner-border\"><\/div><\/div><\/div><br \/>\n<h4 class=\"orga-headline\"><\/h4><ul><li><a href=\"#projektleiter-38\" class=\"open_popup no-scroll\" onclick=\"attach_magnific_popup(event)\">PD Dr. Simone H\u00e4berlein<\/a><\/li><\/ul><div id=\"projektleiter-38\" class=\"projektleiter-modal mfp-hide\">   <button title=\"Close (Esc)\" type=\"button\" class=\"mfp-close mfp-close-custom\">\u00d7<\/button>   <div class=\"modal-inner\">       <img loading=\"lazy\" decoding=\"async\" style=\"float:right;\" src=\"https:\/\/www.loewe-druid.de\/wp-content\/uploads\/pls2022\/simone-haeberlein.jpg\" width=\"1000\" height=\"667\" \/>       <h4>PD Dr. Simone H\u00e4berlein<\/h4>       <p><p>Justus-Liebig-Universit\u00e4t Gie\u00dfen<br \/>\nBFS, Institut f\u00fcr Parasitologie<br \/>\nSchubertstra\u00dfe 81<br \/>\n35392 Gie\u00dfen<br \/>\nTel.: +49 (0)641-99 38476<br \/>\nFax: +49 (0)641-99 38469<br \/>\nE-Mail:<span class=\"link-mailto\"> <a class=\"email-link\" title=\"\" href=\"mailto:Simone.Haeberlein@vetmed.uni-giessen.de\" target=\"_self\" rel=\"\">Simone.Haeberlein(at)vetmed.uni-giessen(dot)de<\/a><\/span><\/p>\n<p><a href=\"https:\/\/www.uni-giessen.de\/fbz\/fb10\/institute_klinikum\/institute\/parasitologie\/forschung\/schisto\/mitarbeiter\/haeberlein\" target=\"_blank\" rel=\"noopener\">Homepage<\/a><\/p>\n<\/p>   <\/div><\/div><\/p><\/div><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":2035,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"tags":[],"portfolio_entries":[101],"class_list":["post-2230","portfolio","type-portfolio","status-publish","has-post-thumbnail","hentry","portfolio_entries-nachwuchsgruppen-en"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.2 - 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