{"id":2221,"date":"2022-07-25T08:30:25","date_gmt":"2022-07-25T06:30:25","guid":{"rendered":"https:\/\/www.loewe-druid.de\/research\/nachwuchsgruppen-und-professuren\/"},"modified":"2023-11-07T12:16:27","modified_gmt":"2023-11-07T11:16:27","slug":"cfc","status":"publish","type":"page","link":"https:\/\/www.loewe-druid.de\/en\/research\/cfc\/","title":{"rendered":"Core Facility Cluster"},"content":{"rendered":"<div  class='flex_column av-58wgcw-7661a2a86835322794d7bbc1b17c2a33 av_one_full  avia-builder-el-0  el_before_av_hr  avia-builder-el-first  first flex_column_div  '     ><section  class='av_textblock_section av-l8wovl15-f2f355f0abcad737fa62395bbd0294eb '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><h3><strong>Core Facility Cluster Drug Development to support translational projects within the LOEWE center DRUID<\/strong><\/h3>\n<p>The development of chemical compounds into drugs is a complex and time-consuming process before a substance can be used for the treatment of human disease.<\/p>\n<p>A major focus of the <strong>LOEWE Centre DRUID<\/strong> is the development of drugs against neglected and poverty-associated tropical diseases. This development is generally carried out in the following sequential steps: 1. identification of initial inhibitors (so-called hits), 2. improvement of these substances in terms of their biological efficacy, 3. development of a lead structure that already has drug-typical properties (no acute toxicity, sufficient potency, etc.), 4. extensive testing of this substance for toxicity in model systems and analysis of pharmacodynamics and pharmacokinetics.<\/p>\n<p>This is followed by the application of the substance(s) in animal models and finally production under GMP conditions (preclinical phase) and subsequent clinical trials.<\/p>\n<p>Often, academic collaborations developing compounds get stuck at a very early concept stage due to a lack of <strong>coordinated guidance, appropriate technology centres and industry support<\/strong> to develop the first inhibitors identified into a promising drug.<\/p>\n<p>In order to close this potential gap, a total of three research groups from the Universities of Marburg and Giessen have joined forces within DRUID to form a <strong>Core Facility Cluster Drug Development<\/strong>. This cluster consists of three service units (Core Facilities, CF), which represent the central steps of the early preclinical development process.<\/p>\n<\/div><\/section><\/div><div  class='hr av-belmw0-b4324a468efca7f12a1ea0f04f13c516 hr-default  avia-builder-el-2  el_after_av_one_full  el_before_av_two_fifth '><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div><\/p>\n<div  class='flex_column av-9gg4og-f9c690b226eb42ade2d1f4cd8648fd74 av_two_fifth  avia-builder-el-3  el_after_av_hr  el_before_av_three_fifth  first flex_column_div  '     ><p>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-lhopd4oo-b471554e72ba46e8c20b9d98fd91a883\">\n.avia-image-container.av-lhopd4oo-b471554e72ba46e8c20b9d98fd91a883 img.avia_image{\nbox-shadow:none;\n}\n.avia-image-container.av-lhopd4oo-b471554e72ba46e8c20b9d98fd91a883 .av-image-caption-overlay-center{\ncolor:#ffffff;\n}\n<\/style>\n<div  class='avia-image-container av-lhopd4oo-b471554e72ba46e8c20b9d98fd91a883 av-styling- avia-align-center  avia-builder-el-4  el_before_av_hr  avia-builder-el-first '   itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><div class=\"avia-image-container-inner\"><div class=\"avia-image-overlay-wrap\"><img decoding=\"async\" fetchpriority=\"high\" class='wp-image-244 avia-img-lazy-loading-not-244 avia_image ' src=\"https:\/\/www.loewe-druid.de\/wp-content\/uploads\/pls2022\/peter-kolb-300x200.jpg\" alt='' title='Peter Kolb'  height=\"200\" width=\"300\"  itemprop=\"thumbnailUrl\" srcset=\"https:\/\/www.loewe-druid.de\/wp-content\/uploads\/pls2022\/peter-kolb-300x200.jpg 300w, https:\/\/www.loewe-druid.de\/wp-content\/uploads\/pls2022\/peter-kolb-768x512.jpg 768w, https:\/\/www.loewe-druid.de\/wp-content\/uploads\/pls2022\/peter-kolb-705x470.jpg 705w, https:\/\/www.loewe-druid.de\/wp-content\/uploads\/pls2022\/peter-kolb.jpg 1000w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/div><\/div><\/div><br \/>\n<div  class='hr av-7yi1k0-efdd7da5cdf00954caec5c1928cab676 hr-default  avia-builder-el-5  el_after_av_image  el_before_av_image '><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div><br \/>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-lhopdj5v-a9691db733d253f00dde5afa55f3b243\">\n.avia-image-container.av-lhopdj5v-a9691db733d253f00dde5afa55f3b243 img.avia_image{\nbox-shadow:none;\n}\n.avia-image-container.av-lhopdj5v-a9691db733d253f00dde5afa55f3b243 .av-image-caption-overlay-center{\ncolor:#ffffff;\n}\n<\/style>\n<div  class='avia-image-container av-lhopdj5v-a9691db733d253f00dde5afa55f3b243 av-styling- avia-align-center  avia-builder-el-6  el_after_av_hr  el_before_av_hr '   itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><div class=\"avia-image-container-inner\"><div class=\"avia-image-overlay-wrap\"><img decoding=\"async\" fetchpriority=\"high\" class='wp-image-246 avia-img-lazy-loading-not-246 avia_image ' src=\"https:\/\/www.loewe-druid.de\/wp-content\/uploads\/pls2022\/wibke-diederich-300x200.jpg\" alt='' title='Wibke Diederich'  height=\"200\" width=\"300\"  itemprop=\"thumbnailUrl\" srcset=\"https:\/\/www.loewe-druid.de\/wp-content\/uploads\/pls2022\/wibke-diederich-300x200.jpg 300w, https:\/\/www.loewe-druid.de\/wp-content\/uploads\/pls2022\/wibke-diederich-768x511.jpg 768w, https:\/\/www.loewe-druid.de\/wp-content\/uploads\/pls2022\/wibke-diederich-705x470.jpg 705w, https:\/\/www.loewe-druid.de\/wp-content\/uploads\/pls2022\/wibke-diederich.jpg 1000w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/div><\/div><\/div><br \/>\n<div  class='hr av-5m2cjk-f80ca4c1651a3e599a13b679d57ced77 hr-default  avia-builder-el-7  el_after_av_image  el_before_av_image '><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div><br \/>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-lhopdyyl-fb799677ebbafbc8da0da447ccec89c1\">\n.avia-image-container.av-lhopdyyl-fb799677ebbafbc8da0da447ccec89c1 img.avia_image{\nbox-shadow:none;\n}\n.avia-image-container.av-lhopdyyl-fb799677ebbafbc8da0da447ccec89c1 .av-image-caption-overlay-center{\ncolor:#ffffff;\n}\n<\/style>\n<div  class='avia-image-container av-lhopdyyl-fb799677ebbafbc8da0da447ccec89c1 av-styling- avia-align-center  avia-builder-el-8  el_after_av_hr  avia-builder-el-last '   itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><div class=\"avia-image-container-inner\"><div class=\"avia-image-overlay-wrap\"><img decoding=\"async\" fetchpriority=\"high\" class='wp-image-228 avia-img-lazy-loading-not-228 avia_image ' src=\"https:\/\/www.loewe-druid.de\/wp-content\/uploads\/pls2022\/joachim-geyer-300x200.jpg\" alt='' title='Joachim Geyer'  height=\"200\" width=\"300\"  itemprop=\"thumbnailUrl\" srcset=\"https:\/\/www.loewe-druid.de\/wp-content\/uploads\/pls2022\/joachim-geyer-300x200.jpg 300w, https:\/\/www.loewe-druid.de\/wp-content\/uploads\/pls2022\/joachim-geyer-768x512.jpg 768w, https:\/\/www.loewe-druid.de\/wp-content\/uploads\/pls2022\/joachim-geyer-705x470.jpg 705w, https:\/\/www.loewe-druid.de\/wp-content\/uploads\/pls2022\/joachim-geyer.jpg 1000w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/div><\/div><\/div><\/p><\/div>\n<div  class='flex_column av-45umsg-e582648aff1ede8388f4804a5c9a9b5c av_three_fifth  avia-builder-el-9  el_after_av_two_fifth  el_before_av_hr  flex_column_div  '     ><section  class='av_textblock_section av-lhojs2lm-13a9321c6fdc6601ef0edc1d3a5019e3 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><h4><strong>CF &#8211; Chemoinformatics &amp; Molecular AI &#8211; <\/strong>Prof. Dr. Peter Kolb<\/h4>\n<p>Institut f\u00fcr Pharmazeutische Chemie<br \/>\nPhilipps-Universit\u00e4t Marburg<br \/>\nMarbacher Weg 8<br \/>\n35032 Marburg<br \/>\nTel.: +49 (0)6421-28 25908<br \/>\nFax: +49 (0)6421-28 26652<br \/>\nE-Mail: <a class=\"mail\" href=\"mailto:peter.kolb@uni-marburg.de\">peter.kolb(at)uni-marburg(dot)de<\/a><br \/>\n<span style=\"color: #ffffff;\">1<\/span><\/p>\n<\/div><\/section><br \/>\n<section  class='av_textblock_section av-lhojsiwx-98af3480af0a7128750386d7b1c1a319 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><h4><\/h4>\n<h4><strong>CF &#8211; Medicinal Chemistry &#8211; <\/strong>Prof. Dr. Wibke Diederich<\/h4>\n<p>Institut f\u00fcr Pharmazeutische Chemie<br \/>\nZentrum f\u00fcr Tumor- und Immunbiologie<br \/>\nPhilipps-Universit\u00e4t Marburg<br \/>\nHans-Meerwein-Stra\u00dfe 3<br \/>\n35043 Marburg<br \/>\nTel.: +49 (0)6421-28 25810<br \/>\nFax: +49 (0)6421-28 26254<br \/>\nE-Mail: <a class=\"mail\" href=\"mailto:wibke.diederich@staff.uni-marburg.de\">wibke.diederich(at)staff.uni-marburg(dot)de<\/a><br \/>\n<span style=\"color: #ffffff;\">1<\/span><\/p>\n<\/div><\/section><br \/>\n<section  class='av_textblock_section av-lhojt3at-a031a4c396e647b0173f461c401da49b '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><h4><strong>CF &#8211;<em> in vivo<\/em><\/strong>\u00a0<strong>Pharmacokinetics\/Pharmacodynamics &#8211; <\/strong>Prof. Dr. Joachim Geyer<\/h4>\n<p>Institut f\u00fcr Pharmakologie und Toxikologie<br \/>\nJustus-Liebig-Universit\u00e4t Gie\u00dfen<br \/>\nSchubertstra\u00dfe 81<br \/>\n35392 Gie\u00dfen<br \/>\nPhone: +49 (0)641-99 38404<br \/>\nE-Mail: <a class=\"mail\" href=\"mailto:joachim.m.geyer@vetmed.uni-giessen.de\">joachim.m.geyer(at)vetmed.uni-giessen(dot)de<\/a><\/p>\n<\/div><\/section><\/p><\/div>\n<div  class='hr av-4e8mpc-a18fee3160358eb7179caf2da53b0824 hr-default  avia-builder-el-13  el_after_av_three_fifth  el_before_av_one_full '><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n<div  class='flex_column av-2k8y0g-83fd051b5c2d3e6c5e0c2f068115d810 av_one_full  avia-builder-el-14  el_after_av_hr  avia-builder-el-last  first flex_column_div  '     ><section  class='av_textblock_section av-lhojihmu-0a8e5565eafa56161352b83628e24d74 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><p>The CFC Drug Development at the FCMH represents a unique platform in the academic field. The services offered are available to all DRUID projects in early preclinical development (no GLP services). In addition, the CFC contributes to the training of scientists in translational research and thus strengthens the professionalisation of the academic field and ultimately the link between industry and academia. In addition, the CFC enables research and translation in therapeutic areas that are traditionally of little interest to industry, such as neglected tropical diseases (NTDs).<\/p>\n<\/div><\/section><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":140,"menu_order":15,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-2221","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Core Facility Cluster - LOEWE-Zentrum DRUID<\/title>\n<meta name=\"description\" content=\"Core Facility Cluster Drug Development for Translational Projects\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.loewe-druid.de\/en\/research\/cfc\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Core Facility Cluster - 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